When you partner with the Center for Vaccines and Immunology (CVI), you gain access to key resources and expertise for preclinical metabolic disease research. Our researchers are experienced in large animal model development and can help you develop and validate novel models of metabolic disorders. Along with our experts, you can access our in-house laboratories that provide qualitative and quantitative analytics on a variety of endpoints.
Coupled with our resources is a depth of experience with large animals. In addition to facilities and personnel dedicated to the study and care of the animals, our on-site diet laboratory provides custom diets to induce specific disease-states against which to test your intervention. We are skilled at sourcing the right animal for the study, including offering unique research opportunities through our colony of metabolic disease and diabetic non-human primates. These animals naturally develop type 2 diabetes in ways that mimic the human progression of the disease. There is a cohort of these animals available at any one time, ready to be used in small trials or pilots.
Key Areas of Research
- Diet-induced metabolic disorders
- Type 2 diabetes
- Type 1 diabetes
- Insulin sensitivity and resistance
- Obesity-related cardiovascular conditions
- NAFLD and NASH
- Lipid and lipoprotein profiling
- Effects of diet on gene expression
- β-cell regeneration